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. 2017 Feb 20;7:42939. doi: 10.1038/srep42939

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effects of combined treatment with U0126 and MK2206 on cell proliferation in DES (A) (n = 14), EES-P (B) (n = 10), EES-S (C) (n = 6), or EES-M (D) (n = 5). Cells were grown on PGS of varying stiffness (2 or 30 kPa) or plastic. Dose 1: U0126 (15 μM) and MK2206 (4.5 μM). Dose 2: U0126 (30 μM) and MK2206 (9 μM). Numerical values are presented as box and whisker plots showing medians and the smallest and largest data points ≤1.5 × IQR from the 25th and 75th percentiles, respectively. *p < 0.05: 2-kPa PGS versus plastic. ^#p < 0.05: 30-kPa PGS versus plastic. ^¶p < 0.05: 2-kPa versus 30-kPa PGS.