Table 3. Suramin inhibition of HEVs.
Group | Name | Strain | Viral load in 0 μM suramin | Viral load reduction | |
---|---|---|---|---|---|
10 μM suramin | 100 μM suramin | ||||
A | CV-A2 | Fleetwood | 6.5 log10 TCID50/ml | 0.3 log10 TCID50/ml | 3.4 log10 TCID50/ml |
CV-A3 | Olson | 4.1 log10 TCID50/ml | 1.4 log10 TCID50/ml | 4.1 log10 TCID50/ml | |
CV-A10 | Kowalik | 6.1 log10 PFU/ml | 2.7 log10 PFU/ml | 6.1 log10 PFU/ml | |
CV-A12 | Texas 12 | 4.8 log10 TCID50/ml | −0.2 log10 TCID50/ml | 4.8 log10 TCID50/ml | |
CV-A16* | shzh05-1 | 9.7 log10 TCID50/ml | 2.0 log10 TCID50/ml | >7.0 log10 TCID50/ml | |
EV-A71 | Fuyang 573 | 6.1 log10 TCID50/ml | 4.8 log10 TCID50/ml | 6.1 log10 TCID50/ml | |
EV-A71 | SH12-276 | 4.3 log10 TCID50/ml | 0.5 log10 TCID50/ml | 2.3 log10 TCID50/ml | |
B | CV-A9 | RO-609/4/80 | 5.9 log10 TCID50/ml | 0.4 log10 TCID50/ml | 2.9 log10 TCID50/ml |
CV-B3 | Nancy | n.a. | no | no | |
CV-B4 | J.V.B. Benschoten | n.a. | no | no | |
ECHO20 | JV-1 | 3.6 log10 TCID50/ml | 0.7 log10 TCID50/ml | 0.7 log10 TCID50/ml | |
ECHO25 | JV-4 | 2.5 log10 TCID50/ml | 0.0 log10 TCID50/ml | −0.2 log10 TCID50/ml | |
C | Poliovirus 1 | Sabin-1 | n.a. | no | no |
Poliovirus 2 | Sabin-2 | n.a. | no | no | |
Poliovirus 3 | Sabin-3 | n.a. | no | no | |
Poliovirus 1 | Mahoney 91 | n.a. | no | no | |
Poliovirus 3 | P3/Leon/37 | n.a. | no | no | |
D | EV-D68 | Fermon | n.a. | no | no |
*Tested in RD cells based on TCID50 titration, which was published in previous study12. n.a.: Data not available. no: Suramin has no inhibition to the tested virus.