a) (Top Panel): Regions of interest exhibiting greater task-related activity than control during (from left to right) Encoding, WWW, Location, Temporal, Object tasks. (Centre Panel): Regions of interest exhibiting greater task-related activity in lean relative to obese individuals during (from left to right) Encoding, WWW, Location, Temporal, Object tasks. (Bottom Panel): Regions of interest exhibiting greater task-related activity in individuals with low IR relative to those with high IR during (from left to right) Encoding, WWW, Location, Temporal, Object. b) Mean activity levels (Task-Control) across regions of interest in lean and obese participants (left) and high and low IR groups (right).