Table 4.

In vitro drug release fitting equation of different formulations

Fitting equation	Parameter	First-order equation	Higuchi equation	Niebergull equation	Hixson–Crowell equation	Ritger–Peppas equation	Weibull equation
Aqueous solution	R2	0.924	0.965	0.918	0.92	0.969	0.971
	AIC	−17.938	−20.019	–	–	−6.234	−6.204
(+) L/NPs	R2	0.892	0.901	0.871	0.878	0.921	0.929
	AIC	−7.317	−9.717	−12.102	−14.181	−1.985	−1.516
(−) L/NPs	R2	0.919	0.884	0.890	0.8968	0.904	0.912
	AIC	−8.468	−9.529	−6.203	−8.283	−0.0374	−0.019

Abbreviations: AIC, Akaike information criterion; L/NPs, lipid nanoparticles.