Table 5.

Pharmacokinetic parameters of dexamethasone in aqueous humor (mean ± SD, n=6)

Key parameters	Aqueous solution	(+) L/NPs	(−) L/NPs
Volume of instillation	1 mL	1 mL	1 mL
Tmax(h)	0.5	6	5
Cmax(μg/L)	14.601±0.309	34.578±0.333	17.126±0.472
AUC0–t(μg/L/h)	39.410±3.779	185.139±2.185	83.353±0.773
MRT (h)	2.434±0.112	5.192±0.329	4.622±0.014

Abbreviations: AUC, area under the curve; L/NPs, lipid nanoparticles; MRT, mean retention time.