Table 1.
Association between BTLA and HVEM expression and clinicopathological factors of gastric cancer patients
| Variable | Case N | BTLA
|
HVEM
|
||||
|---|---|---|---|---|---|---|---|
| Low N (%) | High N (%) | P-valuesa | Low N (%) | High N (%) | P-valuesa | ||
| Age, years | 0.842 | 0.269 | |||||
| <60 | 74 | 54 (73.0) | 20 (27.0) | 44 (59.5) | 30 (40.5) | ||
| ≥61 | 62 | 43 (69.4) | 19 (30.6) | 31 (50.0) | 31 (50.0) | ||
| Gender | 0.642 | 0.545 | |||||
| Male | 95 | 69 (72.6) | 26 (27.4) | 54 (56.8) | 41 (43.2) | ||
| Female | 41 | 28 (68.3) | 13 (31.7) | 21 (51.2) | 20 (48.8) | ||
| Tumor size, cm | 0.244 | 0.141 | |||||
| <5 | 63 | 48 (76.2) | 15 (23.8) | 39 (61.9) | 24 (38.1) | ||
| ≥5 | 73 | 49 (67.1) | 24 (32.9) | 36 (49.3) | 37 (50.7) | ||
| Location | 0.458 | 0.163 | |||||
| Upper third | 16 | 13 (81.2) | 3 (18.8) | 8 (50.0) | 8 (50.0) | ||
| Middle third | 37 | 24 (64.9) | 13 (35.1) | 16 (43.2) | 21 (56.8) | ||
| Lower third | 83 | 60 (72.3) | 23 (27.7) | 51 (61.4) | 32 (38.6) | ||
| Borrmann type | 0.221 | 0.053 | |||||
| I/II | 38 | 30 (78.9) | 8 (21.1) | 26 (68.4) | 12 (31.6) | ||
| III/IV | 98 | 67 (68.4) | 31 (31.6) | 49 (50.0) | 49 (50.0) | ||
| Depth of invasion | 0.284 | 0.011 | |||||
| T1–2 | 29 | 23 (79.3) | 6 (20.7) | 22 (75.9) | 7 (24.1) | ||
| T3–4 | 107 | 74 (69.2) | 33 (30.8) | 53 (49.5) | 54 (50.5) | ||
| Lymph node metastasis | 0.030 | 0.007 | |||||
| No | 43 | 36 (83.7) | 7 (16.3) | 31 (72.1) | 12 (27.9) | ||
| Yes | 93 | 61 (65.6) | 32 (34.4) | 44 (47.3) | 49 (52.7) | ||
| Histological grade | 0.556 | 0.695 | |||||
| Well/moderate | 47 | 35 (74.5) | 12 (25.5) | 27 (57.4) | 20 (42.6) | ||
| Poor | 89 | 62 (69.7) | 27 (30.3) | 48 (53.9) | 41 (46.1) | ||
Note:
a
χ2 test.
Abbreviations: BTLA, B- and T-lymphocyte attenuator; HVEM, herpesvirus entry mediator.