Table 3.

Univariate and multivariate analysis of the prognostic factors in 136 patients with gastric cancer

Variable	Univariate		Multivariate
	Mean survival (months) (95% CI)	P-valuesa	HR (95% CI)	P-valuesb
Age, years		0.694
<60	45.770 (39.861–51.679)
≥61	44.512 (37.794–51.230)
Gender		0.559
Male	46.116 (40.664–51.568)
Female	42.755 (35.346–50.164)
Tumor size, cm		0.031
<5	49.748 (43.019–56.477)
≥5	41.216 (35.496–46.935)
Location		0.256
Upper third	50.035 (36.890–63.179)
Middle third	39.541 (31.480–47.601)
Lower third	46.682 (40.915–49.869)
Borrmann type		0.018
I/II	52.632 (44.091–61.172)
III/IV	42.359 (37.265–47.453)
Depth of invasion		<0.001		0.001
T1–2	67.932 (61.230–74.635)		1 ref
T3–4	39.001 (34.301–43.700)		2.281 (1.418–3.671)
Lymph node metastasis		<0.001		<0.001
No	66.450 (61.032–71.868)		1 ref
Yes	35.442 (30.598–40.286)		1.499 (1.200–1.874)
Histological grade		0.013		0.027
Well/moderate	53.160 (45.886–60.434)		1 ref
Poor	41.031 (35.634–46.428)		1.334 (1.033–1.723)
BTLA expression		0.001
Low	49.537 (44.191–54.883)
High	34.987 (27.835–42.139)
HVEM expression		<0.001		0.010
Low	54.972 (49.226–60.718)		1 ref
High	33.354 (27.630–39.077)		1.857 (1.161–2.970)

Notes:

^aLog-rank test;

^bCox regression test.

Abbreviations: BTLA, B- and T-lymphocyte attenuator; CI, confidence interval; HR, hazard ratio; HVEM, herpesvirus entry mediator; ref, reference.