Figure 2.

Principal side effects and clinical benefit of combination therapy.

Notes: Red squares report range of side effect percent resulted in clinical trials. Green squares contain data about clinical benefits. Yellow squares refer to major clinical endpoint that resulted not statistically significant compared to controls (placebo or monotherapy). References are in the brackets. *No overall difference versus placebo or statin monotherapy (depending on the study); **overall lower than in placebo groups.

Abbreviations: ALT, alanine amino transferase; AST, aspartate amino transferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; VLDL, very-low-density lipoprotein.