Table 1. Top hits from DSF screening.
| Calbiochem collection | Tm shift (°C) | PKIS collection | Tm shift (°C) | Clinical inhibitors | Tm shift (°C) |
|---|---|---|---|---|---|
| Cdk1/2 Inhibitor III | 9.6 | GW300657X | 8.8 | Rebastinib | 12.6 |
| Alsterpaullone, 2-Cyanoethyl | 7.9 | GW416981X | 8.7 | Dabrafenib | 10.4 |
| Indirubin E804 | 7.6 | GW779439X | 8.1 | SNS-032 | 7.0 |
| Cdk2/9 Inhibitor | 7.2 | GW300660X | 6.8 | Milciclib | 6.2 |
| Aurora/Cdk Inhibitor | 6.7 | GW301784X | 6.0 | AZ23 | 5.8 |
| (Z,E)-3-(imidazol-4-ylmethylene)indolin-2-one | 6.7 | GSK238583A | 5.8 | AT9283 | 5.7 |
| Indirubin-3′-monoxime-5-sulphonic acid | 6.7 | SB-732881-H | 5.5 | Ponatinib | 5.5 |
| Flt3 Inhib III | 6.6 | SB-739245-AC | 5.4 | Dinaciclib | 4.8 |
| 5-Iodo-indirubin-3′-monoxime | 6.1 | SB-732881 | 5.2 | PIK-75 | 4.7 |
| SU9516 | 6.0 | GW780056X | 4.8 | Regorafenib | 4.1 |