Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Illustration of anti-CD123 antibody drug conjugates. Anti-CD123 antibody facilitates specific binding with CD123 on the surface of CD123-overexpressed cells and cellular uptake of ADCs. After internalization, the disulfide linker in CD123-CPT is degraded by GSH and results in release of CPT. Then, CPT inhibits tumor cell proliferation and accomplishes the therapeutic effects.
