Figure 3. Serum samples of Burkitt lymphoma patients show a decrease in VAR2CSA-specific IgG.
(A) IgG reactivity to recombinant VAR2CSA in human serum samples from BL patients (n=121) and endemic controls (n=101). Reactivity was detected using anti-human IgG HRP and measured by ELISA. Bars represent means with standard deviations, (B) IgG binding to VAR2CSA-expressing infected erythrocytes in human serum samples from BL patients and endemic controls. Geometric mean fluorescence intensity (MFI) was assessed by flow cytometry using anti-human IgG FITC. Bars represent means with standard deviations.