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. Author manuscript; available in PMC: 2018 Feb 20.
Published in final edited form as: Chem Res Toxicol. 2017 Jan 3;30(2):635–641. doi: 10.1021/acs.chemrestox.6b00374

Figure 1. Structures of electrophiles and adducts.

Figure 1

Figure 1

A) Structures of electrophiles used in these studies, HNE and ONE, and the alkyne analogues, aHNE and aONE. B) Structures of adducts found on PKM2. Cys and His adducts were found with in both HNE and ONE. Michael adducts of HNE were found on Lys while ONE formed the 4-ketoamide adduct on Lys.