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. Author manuscript; available in PMC: 2018 Feb 20.
Published in final edited form as: Chem Res Toxicol. 2017 Jan 3;30(2):635–641. doi: 10.1021/acs.chemrestox.6b00374

Figure 2. PKM2 cross-links occur upon exposure to HNE and ONE.

Figure 2

Figure 2

Recombinant PKM2 was modified in vitro with increasing concentrations of A) HNE or B) ONE for 1 h at 37°C. Staining of SDS-PAGE with Coomassie blue shows cross-linking of PKM2 monomers with increasing concentrations of electrophile.