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. Author manuscript; available in PMC: 2018 Feb 20.
Published in final edited form as: Chem Res Toxicol. 2017 Jan 3;30(2):635–641. doi: 10.1021/acs.chemrestox.6b00374

Figure 6. Oligomer formation inhibits kinase activity in cellular PKM2.

Figure 6

Figure 6

RKO cells were treated with increasing concentrations of HNE or ONE for 1 h, lysed, reduced with NaBH4, and subjected to in vitro PKM2 kinase assays. Data represent the mean ± SD (n = 3), *P < 0.05, **P < 0.01, ***P < 0.001 by ANOVA.