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. Author manuscript; available in PMC: 2018 Feb 20.
Published in final edited form as: Chem Res Toxicol. 2016 Dec 21;30(2):540–551. doi: 10.1021/acs.chemrestox.6b00268

Table 3.

Levels of TSNAs in mainstream smoke of domestic cigarettes tested with the Canadian Intense machine-smoking regimen. The cigarettes are rank ordered from highest to lowest total TSNA yield.


Tobacco-Specific Nitrosamines (ng/cigarette)a, c

Cigarette Products NAB ± SD NNK ± SD NAT ± SD NNN ± SD Total ± SE
Winston Red 100s, HP 41.4 ± 1.9 245.9 ± 21 291.7 ± 16.3 323.3 ± 22.6 902.3 ± 35
Marlboro Red 100s, HP 32.7 ± 3.2 167.6 ± 21.1 272.3 ± 33.8 262.3 ± 29.4 734.9 ± 49.7
Marlboro Green, HP 27.1 ± 2.3 166.3 ± 10.7 259.4 ± 13.2 239.9 ± 16.8 692.7 ± 23.9
Marlboro Red, SP 30.7 ± 3.7 159.6 ± 14.8 248.7 ± 17.0 249.7 ± 28.4 688.7 ± 36.3
Winston Red, HP 32.6 ± 1.8 179.1 ± 3.7 230.4 ± 16.3 240.7 ± 15.2 682.8 ± 22.7
Marlboro Red 100s, SP 33 ± 1.7 143.7 ± 19.3 253.3 ± 21.6 242.9 ± 33.8 672.9 ± 44.7
B&H Green 100s, HP 29.6 ± 2.3 144.9 ± 18.7 240.6 ± 10,9 241.7 ± 25.9 656.9 ± 33.8
Salem Green, HP 29.2 ± 3.2 148.7 ± 22.9 245.7 ± 30.3 231.4 ± 26.1 654.9 ± 46.3
Marlboro Red Label, HP 28.8 ± 4.0 146.7 ± 17.9 238.4 ± 19.8 224.6 ± 21 638.6 ± 34.1
Winston Gold, HP 29.9 ± 2.8 166.6 ± 14.8 202.1 ± 32.5 223.9 ± 28.9 622.5 ± 46.1
Marlboro Red, HP 27.9 ± 3.9 136.9 ± 8.9 232 ± 14.9 220 ± 15.9 616.7 ± 23.6
Newport Green 100s, HP 27.7 ± 3.2 109.9 ± 19.5 204.9 ± 11.8 250.9 ± 25.1 593.3 ± 34
Basic Green 100s, HP 24.6 ± 2.2 156.9 ± 17.7 194.6 ± 22.4 207.4 ± 24.9 583.4 ± 38.1
Marlboro Gold 100s, HP 27.7 ± 4.5 123.14 ± 10.4 215.3 ± 15.5 205.6 ± 21.1 571.6 ± 28.2
USA Gold 100s, SP 24.7 ± 2.4 124 ± 11.6 204.9 ± 20.6 215.1 ± 32.8 568.9 ± 40.5
Basic Gold 100s, SP 25.2 ± 1.6 134 ± 19.5 183 ± 13.2 219.9 ± 16.8 562 ± 28.9
Marlboro Gold 100s, SP 25.8 ± 1.9 123 ± 15.4 205.9 ± 18.5 197.4 ± 16.6 552.1 ± 24.3
Newport Green, SP 24.8 ± 2.6 103.4 ± 14.3 186.6 ± 17.1 237 ± 28.5 551.7 ± 36.3
Basic Gold 100s, HP 24.7 ± 2.8 142 ± 10.1 187.7 ± 24.1 193.1 ± 17.5 547.6 ± 31.6
Marlboro Gold, HP 24.5 ± 1.1 115 ± 17.5 196 ± 18.4 206.1 ± 38.4 541.6 ± 46.1
Newport Green, HP 25.1 ± 2.9 101.6 ± 18.7 186.7 ± 17.1 221.1 ± 16 534.5 ± 30.0
True Silver, SP 25.8 ± 2.8 74.9 ± 11.3 192 ± 13.7 234.9 ± 21.1 527.6 ± 27.6
B&H Luxury 100s, SP 25.4 ± 2.5 108.1 ± 43.4 191 ± 10.4 192.1 ± 25.8 516.7 ± 51.7
Salem Gold, HP 24 ± 1.3 127.4 ± 22.5 180.4 ± 17.8 180.9 ± 11 512.6 ± 30.7
Marlboro Menthol Gold, HP 20.6 ± 1.7 119 ± 16.7 185.9 ± 17.7 186.1 ± 23.4 511.6 ± 33.9
Merit Gold, SP 22.9 ± 1.4 108.4 ± 8.1 190.7 ± 7.4 188.9 ± 8.4 510.9 ± 13.9
Salem Gold 100s, HP 23 ± 2.9 138.1 ± 25.1 180 ± 22.2 167.9 ± 20.8 509 ± 39.5
Winston White 100s, HP 24.3 ± 2.3 139.4 ± 17.1 158 ± 8.3 184.3 ± 9.4 506 ± 21.4
Basic Blue 100s, HP 21.9 ± 2.4 129.4 ± 13.5 161.4 ± 10.6 185.6 ± 8.1 498.3 ± 19.0
Marlboro Gold, SP 22.5 ± 1.6 105.5 ± 11 181.3 ± 16.6 179.7 ± 23.8 488.9 ± 31.1
Kool Green, HP 21.8 ± 1.6 123.3 ± 25.6 182.3 ± 20.1 158.6 ± 23.1 486 ± 40
Kool Green, SP 22.1 ± 1.9 116.7 ± 10.2 181.7 ± 19.8 156.7 ± 27.4 477.2 ± 35.3
Marlboro Silver 100s, HP 21.5 ± 2.7 97.4 ± 63.5 175.7 ± 13.3 181.3 ± 13.7 475.8 ± 66.4
Parliament Blue, HP 22.9 ± 2.8 101.2 ± 34.5 176.6 ± 27 170.6 ± 26 471.2 ± 51
Marlboro Silver, HP 21.2 ± 1.5 95.3 ± 26.7 179.4 ± 34.3 175.1 ± 20.2 471 ± 48.1
Vantage Multicolor, SP 21.1 ± 2.6 142.4 ± 16.9 153 ± 114.7 154.4 ± 19.5 470.9 ± 29.8
Maverick Gold 100s, HP 22.1 ± 1.8 107 ± 13.2 163.4 ± 19.8 171.1 ± 20.8 463.7 ± 31.6
VA Slim Gold, HP 19.8 ± 1.5 107.6 ± 8.5 165.9 ± 18.6 156.9 ± 13.6 450.1 ± 25
NOW Gold 100s, SP 20.7 ± 1.3 95.7 ± 11 161 ± 21.9 152.8 ± 10.5 430 ± 26.8
Carlton White 100s, HP 21 ± 1.6 107.2 ± 12.4 154 ± 13.8 135 ± 12.7 417.2 ± 22.6
Camel Filters, HP 21.5 ± 1.8 90.6 ± 20 161.9 ± 28.4 140.1 ± 31 414.1 ± 46.6
Pall Mall Blue, HP 18 ± 2.4 113.1 ± 10 134.1 ± 10.6 145.6 ± 15.6 410.9 ± 21.4
Capri Magenta SS-H 19.5 ± 1.5 76.8 ± 8.9 166.6 ± 22.3 145.7 ± 38.1 408.6 ± 45.1
Doral Gold, HP 16.6 ± 1.1 140.1 ± 32.6 123.3 ± 15.1 128.6 ± 27.6 408.6 ± 45.3
Doral Silver 100s, HP 17.3 ± 3.5 109.5 ± 11.5 132.8 ± 16.4 138.6 ± 25 398.1 ± 32.1
Kent Golden, SP 20.3 ± 2.0 71.1 ± 12.4 147.7 ± 29.3 150.7 ± 26.6 389.8 ± 41.5
Camel Blue, HP 19.1 ± 2.2 80.9 ± 15.3 151.9 ± 14 131.9 ± 27.3 383.6 ± 34.3
Misty Blue Slims, HP 16.2 ± 1.7 101 ± 21.4 124 ± 22.9 130.3 ± 29.6 371.4 ± 43.2
Salem Silver 100s, HP 18.5 ± 1.2 90.1 ± 23.7 133.7 ± 24.5 128.7 ± 23.8 371 ± 41.6
American Spirit Blue HPb 6.5 ± 1.0 39.9 ± 3.7 44.3 ± 2.5 32.8 ± 3.0 123.5 ± 5.5
2R4F 27.8 ± 2 265.2 ± 26.5 226.5 ± 17.8 309.4 ± 26.6 828.9 ± 49.9

NAB, N-nitrosoanabasine; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NAT, N-nitrosoanatabine; and NNN, N-nitrosonornicotine; Total, (Sum of NNK, NAB, NAT, and NNN) (ng/cigarette); B&H, Benson and Hedges; HP, Hard Pack; SP, Soft Pack; SD, Standard deviation;

a

N= 7-replicate measurements; SE, Standard error;

b

100% Flue-cured tobacco;

c

American blend cigarette products