Table 1.
hinge | Variable | target proteases | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
position human | 15 | 14 | 13 | 12 | 11 | 10 | 9 | 8 | 7 | 6 | 5 | 4 | 3 | 2 | 1 | 1′ | 2′ | 3′ | 4′ | |
SerpinB3 | G | A | E | A | A | A | A | T | A | V | V | G | F | G | S | S | P | T | S | Papain, Cathepsin L, S, K |
SerpinB4 | * | V | * | * | * | * | * | * | * | * | * | V | V | E | L | * | S | P | * | Chymase, Cathepsin G, Der P, Granzyme M |
Mouse | ||||||||||||||||||||
serpinb3a | G | T | E | A | A | A | A | T | G | V | E | V | S | L | T | S | A | Q | I | Cathepsin K, L, S, V, G, papain, Der P, HMC |
serpinb3b | * | * | * | * | * | * | * | * | * | * | * | * | * | V | R | * | * | * | * | Cathepsin L, G |