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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Semin Cell Dev Biol. 2016 Aug 20;63:68–78. doi: 10.1016/j.semcdb.2016.08.015

Figure 2. Overview of SOX4 and SOX9 function in pancreas development.

Figure 2

(A) A schematic showing a positive feedback loop between PDX1 and SOX9 that promotes pancreatic specification while repressing intestinal fate at E8.75 [modified from 70]. (B) During primary transition, FGF10 from the pancreatic mesenchyme is transduced by FGFR2b to maintain SOX9 expression in the multipotent pancreatic progenitors. SOX9 in turn maintains FGFR2b expression in the same cell. SOX9 also regulates HES1 expression. The interplay between SOX9, FGF10, FGFR2b, and HES1 preserves the pancreatic cell fate [modified from 72]. (C) Different levels of Notch signaling control endocrine versus ductal cell fate through regulating expression of SOX9 and HES1 during secondary transition [modified from 65]. (D) A proposed model showing that SOX4 and NGN3 co-bind the promoters of downstream transcription factors to regulate differentiation and maturation of β-cells in mouse and α-cells in zebrafish.