Table 4.

Medications reported to induce xerostomia, salivary gland hypofunction, or sialorrhea with weaker level of evidence

Drug name	Number of citations for:				Sources per level of evidence (n)		Total publications (n)	References
	Oral ‘dryness’		Sialorrhea
	Xerostomia	SGH	Subjective	Objective	A3	B3
Amiloride	0	1	0	0	1	0	1	[14]
Apraclonidine	1	0	0	0	0	1	1	[26]
Asimadoline	1	0	0	0	0	1	1	[252]
Atomoxetine	1	0	0	0	0	1	1	[253]
Biperiden	1	1	0	0	1	0	1	[14]
Chlorpheniramine	1	0	0	0	0	1	1	[254]
Chlorprothixene	0	1	0	0	1	0	1	[14]
Cisplatin	1	0	0	0	0	1	1	[255]
Clomipramine	3	0	0	0	0	3	3	[90, 95, 145]
Cyclothiazide	0	1	0	0	1	0	1	[14]
Cytisine	1	0	0	0	0	1	1	[256]
Diltiazem	0	1	0	0	1	0	1	[14]
Dimenhydrinate	2	0	0	0	0	2	2	[167, 254]
Diphenhydramine	1	0	0	0	0	1	1	[254]
Disopyramide	1	0	0	0	1	0	1	[14]
Flupirtine	1	0	0	0	0	1	1	[257]
Granisetron	1	0	0	0	0	1	1	[258]
Guanfacine	2	0	0	0	0	2	2	[53, 259]
Interleukin-2a	0	1	0	0	1	0	1	[14]
Ipratropium	1	0	0	0	0	1	1	[260]
Levomepromazine	0	1	0	0	1	0	1	[14]
Maprotiline	1	1	0	0	1	0	1	[14]
Mazindol	1	0	0	0	0	1	1	[100]
Melperone	0	1	0	0	1	0	1	[14]
Mepyramine	1	0	0	0	0	1	1	[254]
Metiamide	0	1	0	0	1	0	1	[14]
Milnacipran	3	0	0	0	0	3	3	[85, 261, 262]
Mirtazapine	2	0	0	0	0	2	2	[18, 263]
Moclobemide	1	0	0	0	0	1	1	[112]
Modafinil	2	0	0	0	0	2	2	[90, 264]
Mosapride	1	0	0	0	0	1	1	[265]
Moxifloxacin	1	0	0	0	0	1	1	[266]
Moxonidine	3	0	0	0	0	3	3	[50, 53, 267]
Nefazodone	2	0	0	0	0	2	2	[268, 269]
Oxitropium	1	0	0	0	0	1	1	[260]
Perindopril	1	0	0	0	0	1	1	[270]
Pethidine	0	1	0	0	1	0	1	[14]
Phenelzine	1	0	0	0	0	1	1	[113]
Pheniramine	0	1	0	0	0	1	1	[254]
Promazine	1	0	0	0	0	1	1	[157]
Protriptyline	2	0	0	0	0	2	2	[90, 100]
Pseudoephedrine	1	0	0	0	0	1	1	[207]
Rilmenidine	2	0	0	0	0	2	2	[53, 266]
Selegiline	1	1	0	0	1	1	2	[14, 112]
Thioridazine	2	1	0	0	1	0	1	[14]
Tianeptine	1	0	0	0	1	0	1	[271]
Triprolidine	1	0	0	0	0	1	1	[254]
Zimelidine	0	1	0	0	1	0	1	[14]

SGH salivary gland hypofunction