Table 3.
Hypothesis testing for factors affecting pharmacokinetics of amikacin
| Question | OFV | P value | |
|---|---|---|---|
| Full modela | 330.7 | ||
| Is CL proportional to CCrb? | Full model vs. θ 1 = 0 | 365.8 | <0.001 |
| Is V1 proportional to weight? | Full model vs. θ 2 = 0 | 338.6 | <0.001 |
Final estimates of population pharmacokinetic parameters for amikacin
CCr creatinine clearance, CL total body clearance, OFV objective function value, V 1 volume of distribution in the central compartment
aCL = θ 1(CCr/60.0), V 1 = θ 2(weight/49.5)
bCCr estimates calculated according to the Cockcroft–Gault equation