| A 15-mg/kg once-daily dosage of amikacin is recommended as the initial dosage to get higher probability to achieve the pharmacodynamic/pharmacodynamic target and cumulative fraction of response with lower toxicity. |
| As its maintenance dosage, the 15 mg/kg/day amikacin dosage is needed for a minimal inhibitory concentration (MIC) of ≤4 μg/mL, and amikacin monotherapy for a MIC of ≥8 μg/mL should be avoided, especially in patients with bacteremia or pneumonia. |
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