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. 2017 Jan 10;17(1):219–224. doi: 10.1007/s40268-016-0170-8
Saliva sampling offers an easy and non-invasive method as compared with plasma sampling.
Azithromycin pharmacokinetics and bioequivalence metrics in saliva were compared with plasma, and a good correlation was demonstrated.
Azithromycin is considered a class I drug based on the Salivary Excretion Classification System (SECS), and saliva sampling could be used as an alternative to plasma sampling to characterize the drug’s pharmacokinetics and bioequivalence in humans.