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. 2017 Feb 21;5:13. doi: 10.3389/fcell.2017.00013

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Copyright © 2017 Watanabe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gap junction proteins. (A) Relationship among three types of gap junction proteins: connexins, innexins, and pannexins (Baranova et al., 2004). (B) Structure of connexin proteins. N: N-terminus; TM: transmembrane domain; EL: extracellular loop; IL: intracellular loop; C: C-terminus (Kumar and Gilula, 1996). (C) Schematic presentation of a gap junction (Kumar and Gilula, 1996). (D) Phylogenic relationship between human and zebrafish connexins (Eastman et al., 2006; Cruciani and Mikalsen, 2007). (E) Sequence alignment of N-terminal domains of human and zebrafish alpha-type connexins (Connexin sequences were obtained from genome data base in Sanger Institute, http://www.sanger.ac.uk/).