Figure 2.

Borrelia burgdorferi vascular interactions and transmigration. B. burgdorferi forms three types of vascular interactions: transient/tethering, dragging, and stationary adhesion. Decorin-binding protein A (DbpA) promotes transient/tethering with endothelial cells. Fibronectin-binding protein (BBK32) is involved in all three types of interactions. Stationary interaction through BBK32 may be through direct interaction with the endothelial surface or through a fibronectin bridge (Fn) to a host integrin. P66 also interacts with integrins and is important for transmigration of B. burgdorferi. Figure is a modification of Moriarty et al. (86).