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Schematic diagram summarizing the functions and molecular changes associated with altered chaperone protein expression following CNS and PNS axonal injury. ER, endoplamic reticulum; UPR, unfolded protein response; NRG, neuregulin; Bcl2, B-cell lymphoma 2; BAG1, Bcl-2-associated athanogene-1; AKT, AKT8 virus oncogene cellular homolog; p38, p38 mitogen-activated protein kinase.
