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. 2017 Feb 21;11:79. doi: 10.3389/fnins.2017.00079

Table 1.

Expression of chaperone proteins after CNS and PNS axotomy.

Protein PNS/CNS, species Tissue Cell type Change Authors
alphaB-crystallin CNS, mouse Spinal cord Astrocytes and oligodendrocytes Decreased Klopstein et al., 2012
PNS, rat DRG Neurons Increased Willis et al., 2005
PNS, mouse Sciatic nerve Schwann cells and neurons Decreased Lim et al., 2017
BAG1 PNS, rat Sciatic nerve Schwann cells Increased Wu et al., 2013
BiP CNS, rat Spinal cord Neurons and glia Unchanged Penas et al., 2007
CNS, rat Spinal cord Neurons and glia Decreased Penas et al., 2011a
Clusterin CNS, rat Hippocampus Astrocytes and neurons Increased Lampert-Etchells et al., 1991
CNS, rat Brain Non-neuronal Increased Zoli et al., 1993
CNS, rat Spinal cord Astrocytes and oligodendrocytes Increased Liu et al., 1998
CNS, rat Spinal cord Glia Increased Liu L. et al., 1995
CNS, rat Red nucleus Neurons and glia Increased Liu et al., 1999
CNS, rat Spinal cord Neurons and glia Increased Klimaschewski et al., 2001
CNS, rat Spinal cord and brain Neurons and glia Increased Törnqvist et al., 1996
PNS, rat Sciatic nerve Non-specific Increased Bonnard et al., 1997
PNS, rat Sciatic nerve Schwann cells Increased Wright et al., 2014
PNS, rat Hypoglossal nerve Neurons and glia Increased Törnqvist et al., 1996
PNS, rat Hypoglossal nerve Neurons and glia Increased Svensson et al., 1995
GRP75 PNS, rat DRG Neurons Increased Willis et al., 2005
GRP94 CNS, rat Spinal cord Neurons and astrocytes Increased Xu et al., 2011
HSP25 CNS and PNS, mouse Spinal cord and sciatic nerve Neurons Increased Murashov et al., 2001
PNS, rat Inferior alveolar nerve Schwann cells, neurons, and endothelial cells Increased Iijima et al., 2003
HSP27 CNS, hamster Retina Retinal ganglion cells Increased Liu et al., 2013
CNS, mouse Spinal cord n/a Increased Yi et al., 2008
CNS, rat Spinal cord n/a Increased Zhang et al., 2010
CNS, rat Spinal cord n/a Increased Park et al., 2007
CNS, rat Spinal cord Neurons Increased Keeler et al., 2012
CNS, rat Brainstem Neurons Increased Vinit et al., 2011
CNS, rat Retina Retinal ganglion cells Increased Hebb et al., 2006
CNS, rat Retina, optic tract, and superior colliculus Retinal ganglion cells and astrocytes Increased Krueger-Naug et al., 2002
CNS, rat Medulla oblongata Neurons Increased Hopkins et al., 1998
CNS, rat Retina, optic nerve, optic tract, lateral geniculate leaflet, visual cortex Non-specific; astrocytes Increased Chidlow et al., 2014
CNS and PNS, rat Sciatic nerve, DRG, spinal cord Neurons Increased w/anterograde transport Costigan et al., 1998
PNS, rat Sciatic nerve Schwann cells Increased Hirata et al., 2003
PNS, rat DRG Neurons Increased Benn et al., 2002
PNS, rat Sciatic nerve Non-specific Increased Klass et al., 2008
PNS, rat Sciatic nerve Non-specific Increased Kim et al., 2001
PNS, rat Sciatic nerve n/a Increased Tsubouchi et al., 2009
HSP30 CNS, goldfish Retina n/a Increased Cauley et al., 1986
HSP32 CNS, mouse Spinal cord n/a Increased Yi et al., 2008
CNS, rat Spinal cord n/a Increased Park et al., 2007
HSP60 PNS, rat DRG Neurons Increased Willis et al., 2005
HSP70 CNS, zebrafish Optic nerve Retinal ganglion cells Increased Nagashima et al., 2011
CNS, rabbit Spinal cord Neurons Increased Sakurai et al., 1997
CNS, mouse Spinal cord n/a Increased Yi et al., 2008
CNS, rat Spinal cord Neurons and glia Increased Gower et al., 1989
CNS, rat Spinal cord Macrophages and glia Increased Mautes and Noble, 2000; Mautes et al., 2000
CNS, rat Spinal cord n/a Increased Park et al., 2007
CNS, rat Spinal cord n/a Increased Sengul et al., 2013
CNS, rat Spinal cord n/a Increased Zhang et al., 2010
CNS, rat Spinal cord Non-specific Increased Song et al., 2001
CNS, rat Spinal cord Neurons Increased Keeler et al., 2012
CNS, rat Spinal cord Non-specific Increased Kalmar et al., 2003
CNS, rat Retina, optic nerve, optic tract, lateral geniculate leaflet, visual cortex Non-specific No change Chidlow et al., 2014
CNS & PNS, dog Spinal cord and DRG Neurons and glia Increased Cízková et al., 2005
PNS, hamster Facial nerve Non-specific Increased New et al., 1989
PNS, frog Sciatic nerve Neurons Retrograde transport Edbladh et al., 1994
PNS, rat Sciatic nerve Non-specific Increased Klass et al., 2008
HSP72 CNS, rat Spinal cord n/a Increased Sharma et al., 2015
CNS, rat Spinal cord Neurons Increased Sharma et al., 2006
CNS, rat Spinal cord Non-specific Increased Tachibana et al., 2002
CNS, rat Spinal cord n/a Increased Chang et al., 2014
PNS, rat External carotid nerve ganglion Schwann cells and neurons Increased Hou et al., 1998
HSP90 CNS, rat Spinal cord n/a Increased nitration Franco et al., 2013
PNS, rat Sciatic nerve Non-specific Increased Klass et al., 2008
HSP90ab1 CNS, rat Spinal cord Non-specific Decreased Zhou et al., 2014
HSPa4 CNS, rat Spinal cord Non-specific Decreased Zhou et al., 2014
HSPe1 CNS, rat Spinal cord Non-specific Decreased Zhou et al., 2014
σ1R PNS, rat DRG Neurons and satellite glia Decreased Bangaru et al., 2013