Figure 4.

Comparability of the model by De Pittà et al. (2009) and our modified version of the model by Dupont et al. (2011) with two different seven-pulse waves of Glu stimulus. The two columns from the left show how the models behaved when the stimulus was a seven-pulse wave with alternating Glu concentrations of 2 nM and 5 μM, pulse duration of 5 s, and period 15 s. The two columns from the right show how the models behaved when the stimulus was a seven-pulse wave with alternating Glu concentrations of 2 nM and 5 μM, pulse duration of 1 s, and period 6 s. With our modified version of the model by Dupont et al. (2011), the Ca²⁺ concentration oscillated even at Glu stimulus of 2 nM, which was not the case with the model by De Pittà et al. (2009).