Table 2.

Details of the model by Lavrentovich and Hemkin (2008).

Equation	Initial condition	Parameter value
$\frac{d{\left[C{a}^{2+}\right]}_{cyt}}{dt}=v_{in}-k_{out}{\left[C{a}^{2+}\right]}_{cyt}+v_{CICR}-v_{SERCA}+k_f\left({\left[C{a}^{2+}\right]}_{ER}-{\left[C{a}^{2+}\right]}_{cyt}\right)$	0.1 μM	k2 = 0.1 μM
		kCaA = 0.15 μM
$\frac{d{\left[C{a}^{2+}\right]}_{ER}}{dt}=v_{SERCA}-v_{CICR}-k_f\left({\left[C{a}^{2+}\right]}_{ER}-{\left[C{a}^{2+}\right]}_{cyt}\right)$	1.5 μM	kCaI = 0.15 μM
		kdeg = $0.08\frac{1}{s}$
$\frac{d{\left[I{P}_3\right]}_{cyt}}{dt}=v_{PLC}-k_{deg}{\left[I{P}_3\right]}_{cyt}$	0.1 μM	kf = $0.5\frac{1}{s}$
		kIP3 = 0.1 μM
$v_{CICR}=4v_{M3}\frac{k_{CaA}^n{\left[C{a}^{2+}\right]}_{cyt}^n}{\left({\left[C{a}^{2+}\right]}_{cyt}^n+k_{CaA}^n\right)\left({\left[C{a}^{2+}\right]}_{cyt}^n+k_{CaI}^n\right)}\frac{{\left[I{P}_3\right]}_{cyt}^m}{{\left[I{P}_3\right]}_{cyt}^m+k_{IP3}^m}\left({\left[C{a}^{2+}\right]}_{ER}-{\left[C{a}^{2+}\right]}_{cyt}\right)$		kout = $0.5\frac{1}{s}$
		kp = 0.3 μM
$v_{PLC}=v_p\frac{{\left[C{a}^{2+}\right]}_{cyt}^2}{{\left[C{a}^{2+}\right]}_{cyt}^2+k_p^2}$		m = 2.2
		n = 2.02
$v_{SERCA}=v_{M2}\frac{{\left[C{a}^{2+}\right]}_{cyt}^2}{{\left[C{a}^{2+}\right]}_{cyt}^2+k_2^2}$		vin = $0.05\frac{\mu M}{s}$
		vM2 = $15\frac{\mu M}{s}$
		vM3 = $40\frac{1}{s}$
		vp = $0.05\frac{\mu M}{s}$

This table shows the original equations, parameter values, and initial conditions given in the original publication. Lavrentovich and Hemkin (2008) were the only ones who presented all the values in the original publication. Some of the parameter values that they modified in their simulations were, however, presented wrongly and a corrigendum was provided. The model has three variables: cytosolic Ca²⁺ concentration (${\left[C{a}^{2+}\right]}_{cyt}$), Ca²⁺ concentration in the ER (${\left[C{a}^{2+}\right]}_{ER}$), and cytosolic IP₃ concentration ([I_P3]cyt).