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. 2017 Feb 21;5:15. doi: 10.3389/fped.2017.00015

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Copyright © 2017 dela Peña-Ponce, Rodriguez-Nieves, Bernhardt, Tuck, Choudhary, Mengual, Mollan, Hudgens, Peter-Wohl and De Paris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-dependent changes in JAK/STAT signaling. (A) The relative increase (Δ) in median pSTAT6 or pSTAT1 activation in infant CD4⁺ T cells from birth to 1 year. (B) A positive correlation (Spearman rank test) between infant age and the pSTAT1:pSTAT6 ratio in infant blood samples that had sufficient blood volume to analyze both pSTAT1 and pSTAT6 activation in response to IFN-γ or IL-4 stimulation, respectively. Each symbol represents an individual infant; infants of different ages are represented by distinct color symbols as described in Figure 1.