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. 2017 Feb 21;5:15. doi: 10.3389/fped.2017.00015

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Copyright © 2017 dela Peña-Ponce, Rodriguez-Nieves, Bernhardt, Tuck, Choudhary, Mengual, Mollan, Hudgens, Peter-Wohl and De Paris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4⁺ T cell differentiation in STAT5 activation. (A,B) The percentages of T(N), T(CM), and T(EM/Eff) CD4⁺ T cells that were activated pSTAT5 in response to IL-2 (A) or IL-7(B), respectively, in infant blood samples collected at birth and 1 year. Each symbol represents an individual infant; horizontal lines represent median values. The gray area indicates median frequencies of adult pSTAT5⁺ CD4⁺T cells (n = 17) with borders representing the 25th and 75th percentiles. (C) The correlation by Spearman rank test between pSTAT5⁺CD4⁺T cells and IL-2Rα⁺ CD4⁺ T cells in infant samples of different ages (colored symbols as explained in Figure 1). Note that we only included samples that were analyzed for both pSTAT5⁺ activation and IL-2Rα⁺ expression.