Table 2.
Cytokine receptor expression.
| Cytokine receptor | Cell type | Median number of cytokine receptors/CD4+ T cell (range) |
Birth versus 10–14 months | 10–14 months versus adult | |||||
|---|---|---|---|---|---|---|---|---|---|
| Birth | 1–3 months | 4–6 months | 7–9 months | 10–14 months | Adult | ||||
| IL-4Rα | CD4+ T | 409 (61–1,026) | 407 (300–412) | 311 (271–429) | 303 (271–451) | 286 (201–662) | 278 (179–368) | NS* | NS |
| CD4+ T (N) | 440 (59–1,106) | 433 (350–434) | 381 (368–505) | 314 (273–380) | 283 (196–996) | 281 (210–423) | NS | NS | |
| CD4+ T (CM) | 324 (57–910) | 360 (252–362) | 247 (230–350) | 275 (250–459) | 287 (196–331) | 265 (172–391) | NS | NS | |
| CD4+ T (EM/Eff) | 449 (83–1,040) | 391 (315–568) | 450 (265–567) | 516 (397–725) | 333 (175–395) | 304 (200–371) | NS | NS | |
| IFN-γR1 | CD4+ T | 1,118 (138–4,738) | 2,019 (1,018–5,247) | 972 (785–1,119) | n.d.** | 834 (627–1,388) | 653 (390–1,824) | NS | p = 0.0057 |
| CD4+ T (N) | 1,202 (137–3,804) | 2,350 (1,172–13,874) | 1,387 (885–1,638) | n.d. | 944 (668–2,756) | 872 (430–3,293) | NS | NS | |
| CD4+ T (CM) | 1,276 (140–5,039) | 2,477 (1,015–4,238) | 883 (783–946) | n.d. | 776 (599–1,159) | 718 (364–2,063) | NS | NS | |
| CD4+ T (EM/Eff) | 783 (133–12,727) | 926 (777–1,687) | 708 (608–817) | n.d. | 640 (594–909) | 568 (392–1,792) | NS | NS | |
| IFN-γR2 | CD4+ T | 686 (105–1,641) | 974 (894–1,072) | 1,527 (813–1,940) | n.d. | 630 (299–1,062) | 635 (271–2,018) | NS | NS |
| CD4+ T (N) | 750 (101–2,102) | 1,581 (1,155–1,826) | 2,525 (1,210–3,842) | n.d. | 860 (413–1,367) | 890 (332–2,213) | NS | NS | |
| CD4+ T (CM) | 564 (71–1,696) | 688 (627–906) | 853 (551–965) | n.d. | 451 (253–856) | 507 (223–2,573) | NS | NS | |
| CD4+ T (EM/Eff) | 624 (151–7,201) | 995 (473–1,379) | 806 (548–1,547) | n.d. | 684 (355–3,409) | 584 (289–1,873) | NS | NS | |
| IL-2Rα | CD4+ T | 696 (214–2,420) | 1,548 (1,369–1,606) | 1,052 (621–1,780) | 1,446 (1,032–1,633) | 1,121 (807–1,815) | 501 (200–1,439) | p = 0.0074 | p = 0.0015 |
| CD4+ T (N) | 610 (158–3,166) | 1,836 (1,407–1,912) | 1,382 (678–2,821) | 2,005 (1,782–2,155) | 1,575 (1,019–2,497) | 420 (238–1,170) | p = 0.0006 | p < 0.0001 | |
| CD4+ T (CM) | 667 (232–2,330) | 1,345 (1,293–1,349) | 975 (696–1,335) | 1,266 (869–1,356) | 981 (607–1,467) | 452 (183–1,176) | p = 0.0378 | p = 0.0010 | |
| CD4+ T (EM/Eff) | 853 (452–2,702) | 1,730 (1,365–1,815) | 1,122 (613–1,661) | 1,469 (947–1,699) | 1,176 (911–2,119) | 659 (220–1,827) | NS | p = 0.0022 | |
| IL-2Rβ | CD4+ T | 338 (45–1,776) | n.d. | 410 (294–704) | n.d. | 289 (207–427) | 266 (145–461) | NS | NS |
| CD4+ T (N) | 444 (46–1,491) | n.d. | 436 (377–3,302) | n.d. | 300 (201–540) | 340 (171–671) | NS | NS | |
| CD4+ T (CM) | 261 (52–3,329) | n.d. | 362 (270–393) | n.d. | 272 (203–383) | 225 (134–457) | NS | NS | |
| CD4+ T (EM/Eff) | 344 (43–3,726) | n.d. | 338 (294–519) | n.d. | 280 (212–347) | 265 (130–457) | NS | NS | |
*NS, not significant; p > 0.05; **n.d., not done.