Table 3.
Cytokine receptor expression.
| Cytokine receptor | Cell type | Percentage of CD4+ T cells expressing specific cytokine receptors (range) |
Birth versus 10–14 months | 10–14 months versus adult | |||||
|---|---|---|---|---|---|---|---|---|---|
| Birth | 1–3 months | 4–6 months | 7–9 months | 10–14 months | Adult | ||||
| IL-4Rα | CD4+ T | 0.4 (0.1–3.8) | 0.3 (0.1–0.3) | 0.4 (0.2–0.4) | 0.4 (0.3–0.6) | 0.2 (0.1–4.0) | 0.5 (0.1–1.2) | NS* | NS |
| CD4+ T (N) | 2.5 (0.2–61.3) | 1.4 (0.2–4.8) | 0.6 (0.6–0.7) | 0.7 (0.6–0.8) | 0.4 (0.1–23.8) | 0.9 (0.2–4.2) | NS | NS | |
| CD4+ T (CM) | 0.2 (0.0–0.7) | 0.1 (0.1–0.2) | 0.3 (0.1–0.3) | 0.3 (0.2–0.5) | 0.2 (0.1–4.8) | 0.4 (0.1–1.7) | NS | NS | |
| CD4+ T (EM/Eff) | 0.6 (0.1–27.0) | 0.1 (0.1–0.2) | 0.1 (0.1–0.3) | 0.6 (0.1–0.7) | 0.2 (0.0–0.6) | 0.2 (0.0–0.6) | p = 0.0114 | NS | |
| IFN-γR1 | CD4+ T | 1.1 (0.2–3.9) | 1.4 (0.8–2.5) | 1.9 (1.3–3.0) | n.d.** | 1.4 (0.5–3.3) | 4.3 (1.3–10.0) | NS | p < 0.0001 |
| CD4+ T (N) | 2.1 (0.3–19.1) | 4.4 (0.8–5.6) | 2.1 (1.7–2.8) | n.d. | 1.5 (0.4–2.5) | 0.8 (0.3–2.7) | NS | NS | |
| CD4+ T (CM) | 0.8 (0.1–3.4) | 1.0 (0.5–1.8) | 1.6 (1.1–2.9) | n.d. | 1.2 (0.4–2.3) | 1.1 (0.3–5.6) | NS | NS | |
| CD4+ T (EM/Eff) | 3.4 (0.6–18.7) | 3.8 (2.9–3.8) | 5.9 (1.8–6.8) | n.d. | 6.3 (1.7–9.3) | 12.6 (3.9–31.7) | NS | p < 0.0001 | |
| IFNγR2 | CD4+ T | 0.5 (0.1–7.0) | 0.6 (0.4–0.7) | 0.5 (0.3–0.7) | n.d. | 0.5 (0.2–0.8) | 0.2 (0.1–1.9) | NS | NS |
| CD4+ T (N) | 3.1 (0.2–53.6) | n.d. | 2.5 (0.6–5.0) | n.d. | 0.4 (0.1–1.0) | 0.3 (0.1–2.3) | p = 0.0292 | NS | |
| CD4+ T (CM) | 0.2 (0.0–3.6) | n.d. | 0.4 (0.1–0.5) | n.d. | 0.3 (0.1–0.8) | 0.1 (0.0–1.0) | NS | NS | |
| CD4+ T (EM/Eff) | 1.2 (0.0–14.7) | n.d. | 0.4 (0.1–0.5) | n.d. | 0.2 (0.0–0.7) | 0.2 (0.0–4.2) | p = 0.0053 | NS | |
| IL-2Rα | CD4+ T | 4.1 (1.2–16.2) | 11.3 (6.9–14.7) | 9.8 (7.1–14.0) | 9.6 (8.6–11.7) | 9.6 (7.9–13.8) | 30.6 (16.2–41.4) | p = 0.0006 | p < 0.0001 |
| CD4+ T (N) | 3.7 (0.5–65.2) | 12.6 (5.4–15.6) | 8.3 (4.4–16.4) | 9.1 (9.0–10.6) | 7.4 (2.9–14.7) | 9.7 (4.6–23.1) | NS | NS | |
| CD4+ T (CM) | 1.8 (0.3–14.9) | 6.4 (5.2–11.6) | 6.2 (4.7–10.6) | 6.4 (4.0–7.1) | 8.1 (5.3–10.3) | 36.8 (21.2–53.8) | p = 0.0016 | p < 0.0001 | |
| CD4+ T (EM/Eff) | 38.3 (0.2–87.5) | 77.0 (44.4–82.5) | 49.8 (29.5–66.5) | 42.2 (34.0–52.0) | 44.2 (36.8–58.3) | 47.4 (27.3–76.4) | NS | NS | |
| IL-2Rβ | CD4+ T | 0.5 (0.1–7.5) | n.d. | 0.2 (0.0–0.3) | n.d. | 0.4 (0.1–2.7) | 0.9 (0.1–4.3) | NS | NS |
| CD4+ T (N) | 0.6 (0.2–11.1) | n.d. | 0.2 (0.0–0.3) | n.d. | 0.2 (0.0–1.8) | 0.2 (0.1–1.7) | NS | NS | |
| CD4+ T (CM) | 0.2 (0.0–1.4) | n.d. | 0.1 (0.0–0.2) | n.d. | 0.3 (0.1–2.2) | 0.7 (0.1–4.4) | NS | NS | |
| CD4+ T (EM/Eff) | 3.0 (0.1–16.1) | n.d. | 0.7 (0.1–1.5) | n.d. | 1.9 (0.2–9.6) | 1.8 (0.1–8.9) | NS | NS | |
*NS, not significant; p > 0.05; **n.d., not done.