Table 3.
Associations of inflammatory markers with CIND and AD stratified by the presence of CeVD, expressed as odds ratios with 95% confidence intervals
| Inflammatory markers | With CeVD∗ |
Without CeVD∗ |
||
|---|---|---|---|---|
| CIND odds ratio (95% CI) | AD odds ratio (95% CI) | CIND odds ratio (95% CI) | AD odds ratio (95% CI) | |
| IL-6 | ||||
| 1st tertile | 1 | 1 | 1 | 1 |
| 2nd tertile | 0.73 (0.3–1.8) | 0.84 (0.2–3.4) | 0.65 (0.3–1.6) | 2.12 (0.6–7.7) |
| 3rd tertile | 0.89 (0.4–2.1) | 0.96 (0.3–3.6) | 0.86 (0.4–2.1) | 1.14 (0.3–4.6) |
| IL-8 | ||||
| 1st tertile | 1 | 1 | 1 | 1 |
| 2nd tertile | 1.00 (0.4–2.4) | 0.31 (0.1–1.5) | 0.58 (0.3–1.3) | 0.74 (0.2–2.6) |
| 3rd tertile | 4.53 (1.5–13.4) | 7.26 (1.2–43.3) | 1.99 (0.7–5.4) | 1.09 (0.2–5.7) |
| TNFα | ||||
| 1st tertile | 1 | 1 | 1 | 1 |
| 2nd tertile | 1.17 (0.5–2.9) | 0.86 (0.2–3.6) | 1.31 (0.6–3.0) | 0.99 (0.3–3.7) |
| 3rd tertile | 1.42 (0.6–3.5) | 1.32 (0.3–5.6) | 1.00 (0.4–2.5) | 1.12 (0.3–4.3) |
Abbreviations: CIND, cognitive impairment no dementia; AD, Alzheimer's disease; CeVD, cerebrovascular disease; CI, confidence interval; IL, interleukin; TNFα, tumor necrosis factor α.
NOTE. N values for CIND with CeVD = 68; AD with CeVD = 53. Bold text indicates P values <.05.
∗
Adjusted for age, gender, education, APOE ε4 carrier, diabetes mellitus, hypertension, and cardiovascular diseases.