Table 4.

Associations of IL-8 (in tertiles) with MRI markers of CeVD, expressed as odds ratios with 95% confidence intervals

Inflammatory marker	WMH (ARWMC ≥ 8), odds ratio (95% CI)∗	Cortical infarct, odds ratio (95% CI)†	≥2 lacunes, odds ratio (95% CI)‡
IL-8
1st tertile	1	1	1
2nd tertile	1.28 (0.7–2.5)	2.10 (0.6–7.6)	0.94 (0.3–3.2)
3rd tertile	2.81 (1.4–5.6)	3.50 (0.9–13.1)	2.70 (0.9–8.4)

Abbreviations: IL, interleukin; MRI, magnetic resonance imaging; CeVD, cerebrovascular disease; WMH, white-matter hyperintensity; ARWMC, age-related white-matter changes; CI, confidence interval; CIND, cognitive impairment no dementia.

NOTE. N values for CIND with CeVD = 68; AD with CeVD = 53. N values for significant WMH (ARWMC ≥ 8) = 118, cortical infarcts = 28, lacunes (≥2) = 37. Bold text indicates P values <.05.

^∗Adjusted for age, gender, education, APOE ε4 carrier, hypertension, diabetes mellitus, cardiovascular diseases, presence of cortical infarct, and lacunes.

^†Adjusted for age, gender, education, APOE ε4 carrier, hypertension, diabetes mellitus, cardiovascular diseases, WMH, and presence of lacunes.

^‡Adjusted for age, gender, education, APOE ε4 carrier, hypertension, diabetes mellitus, cardiovascular diseases, WMH, and presence of cortical infarct.