Table 2.
Cmax | Maximum plasma concentration over the time span specified |
Cmax,ss | Maximum plasma concentration at steady state |
Ctrough,ss | Plasma concentration at a dosing interval after the treatment at steady state (trough concentration at steady state) |
Cav,ss | Average plasma concentration during a dosing interval at steady state, calculated as AUCτ,ss/τt |
Clast | Area under the plasma concentration vs time curve, from time 0 to the last measurable concentration, calculated by the linear/log trapezoidal method |
AUCinf | The area under the plasma concentration vs time curve from time 0 to infinity. AUCinf is calculated as the sum of AUClast plus the ratio of the last measurable plasma concentration to the elimination rate constant; AUCinf=AUClast+Clast/λZ |
AUCτ,sst | Area under the plasma concentration vs time curve during a dosing interval (τ) at steady state, calculated by the linear/log trapezoidal method |
CL | (VVZ-149 injection) The total body clearance after IV administration, calculated as dose/AUCinf |
CL/F | (VVZ-368) Apparent total body clearance after IV administration, calculated as dose/AUCinf |
MRT | Mean residence time from the time of dosing to the time of the last measurable concentration. MRT=AUMClast/AUClast |
PTF | Peak-trough fluctuation, calculated as ((Cmax,ss—Ctrough,ss)/Cav,ss)×100 (%) |
Tmax | Time of the maximum measured plasma concentration |
Tmax,ss | Time of the maximum measured plasma concentration at steady state |
t1/2 | Terminal half-life, calculated as ln(2)/λz |
R | Accumulation ratio, AUCτ,ss/AUC0−τt |
Vd | (VVZ-149 injection) The total volume of distribution after IV administration, calculated as dose/(AUCss×λ) |
Metabolic ratio | Metabolic ratio, AUClast of VVZ-368/AUClast of VVZ-149 injection |
IV, intravenous.