Table 2.

Pharmacokinetic parameters collected in the VVZ-149 protocol

Cmax	Maximum plasma concentration over the time span specified
Cmax,ss	Maximum plasma concentration at steady state
Ctrough,ss	Plasma concentration at a dosing interval after the treatment at steady state (trough concentration at steady state)
Cav,ss	Average plasma concentration during a dosing interval at steady state, calculated as AUCτ,ss/τt
Clast	Area under the plasma concentration vs time curve, from time 0 to the last measurable concentration, calculated by the linear/log trapezoidal method
AUCinf	The area under the plasma concentration vs time curve from time 0 to infinity. AUCinf is calculated as the sum of AUClast plus the ratio of the last measurable plasma concentration to the elimination rate constant; AUCinf=AUClast+Clast/λZ
AUCτ,sst	Area under the plasma concentration vs time curve during a dosing interval (τ) at steady state, calculated by the linear/log trapezoidal method
CL	(VVZ-149 injection) The total body clearance after IV administration, calculated as dose/AUCinf
CL/F	(VVZ-368) Apparent total body clearance after IV administration, calculated as dose/AUCinf
MRT	Mean residence time from the time of dosing to the time of the last measurable concentration. MRT=AUMClast/AUClast
PTF	Peak-trough fluctuation, calculated as ((Cmax,ss—Ctrough,ss)/Cav,ss)×100 (%)
Tmax	Time of the maximum measured plasma concentration
Tmax,ss	Time of the maximum measured plasma concentration at steady state
t1/2	Terminal half-life, calculated as ln(2)/λz
R	Accumulation ratio, AUCτ,ss/AUC0−τt
Vd	(VVZ-149 injection) The total volume of distribution after IV administration, calculated as dose/(AUCss×λ)
Metabolic ratio	Metabolic ratio, AUClast of VVZ-368/AUClast of VVZ-149 injection

IV, intravenous.