Table 2.
Cox regression analysis for overall survival
| Variable | p Value | HR | 95% CI |
|---|---|---|---|
| Age | |||
| <25 | 1 | ||
| 25–50 | 0.115 | 1.59 | 0.89 to 2.82 |
| >50 | 0.006 | 2.22 | 1.25 to 3.92 |
| Tumour presentation (‘whoops’* vs primary) | 0.828 | 1.04 | 0.75 to 1.43 |
| Tumour location (lower vs upper) | 0.336 | 1.14 | 0.87 to 1.50 |
| Tumour size, cm | 0.000 | 1.06 | 1.04 to 1.08 |
| Depth | |||
| Deep | 1 | ||
| Superficial | 0.561 | 0.90 | 0.64 to 1.28 |
| Deep and superficial | 0.877 | 1.04 | 0.63 to 1.71 |
| Histopathology | |||
| Angiosarcoma | 1 | ||
| MPNST† | 0.005 | 3.29 | 1.43 to 7.54 |
| Myxofibrosarcoma | 0.060 | 2.15 | 0.97 to 4.78 |
| Synovial sarcoma | 0.027 | 2.59 | 1.12 to 6.02 |
| Spindle cell sarcoma | 0.030 | 2.51 | 1.09 to 5.77 |
| Sarcoma NOS‡ | 0.057 | 2.66 | 0.97 to 7.27 |
| MFH/UPS§ | 0.025 | 2.68 | 1.13 to 6.37 |
| Surgical margin (mm) | |||
| 0 | 1 | ||
| ≤2 | 0.433 | 0.89 | 0.66 to 1.20 |
| >2 | 0.319 | 0.83 | 0.58 to 1.20 |
| Type of surgery (limb-sparing vs amputation) | 0.478 | 0.86 | 0.56 to 1.31 |
| Local recurrence (yes vs no)¶ | 0.000 | 3.42 | 2.55 to 4.60 |
*Incomplete excision elsewhere prior to referral.
†Malignant peripheral nerve sheath tumour.
‡Not otherwise specified.
§Malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma.
¶Time-dependent variable.