Table 3.

HRs and 95% CIs for all prognostic factors and all transitions in the multistate model

	Trans 1: ANED → LR			Trans 2: ANED → DM/Death			Trans 3: LR → DM/Death
Variable	p Value	HR	95% CI	p Value	HR	95% CI	p Value	HR	95% CI
Age
<25		1			1			1
25–50	0.649	0.76	0.23 to 2.50	0.077	1.64	0.95 to 2.85	0.413	0.50	0.10 to 2.60
>50	0.955	1.03	0.32 to 3.31	0.023	1.90	1.09 to 3.29	0.302	0.47	0.11 to 1.97
Tumour presentation (‘whoops’* vs primary)	0.344	1.43	0.68 to 3.03	0.586	0.91	0.66 to 1.26	0.539	1.39	0.48 to 4.03
Tumour location (lower vs upper)	0.116	0.61	0.33 to 1.13	0.919	1.01	0.78 to 1.32	0.474	1.43	0.54 to 3.83
Tumour size, cm	0.018	1.06	1.01 to 1.11	0.000	1.06	1.04 to 1.08	0.114	1.05	0.99 to 1.12
Depth
Deep		1			1
Superficial	0.093	0.51	0.23 to 1.12	0.653	0.92	0.66 to 1.30
Deep and superficial	0.226	0.26	0.03 to 2.33	0.253	1.31	0.82 to 2.09
Histopathology
Angiosarcoma		1			1
MPNST†	0.034	0.23	0.06 to 0.90	0.845	1.08	0.51 to 2.26
Myxofibrosarcoma	0.085	0.34	0.10 to 1.16	0.777	0.90	0.44 to 1.84
Synovial sarcoma	0.023	0.21	0.05 to 0.80	0.972	0.99	0.47 to 2.07
Spindle cell sarcoma	0.078	0.32	0.09 to 1.14	0.910	0.96	0.46 to 2.01
Sarcoma NOS‡	0.918	0.90	0.13 to 6.14	0.702	0.82	0.31 to 2.22
MFH/UPS§	0.032	0.19	0.04 to 0.87	0.560	1.26	0.58 to 2.76
Surgical margin (mm)
0		1			1			1
≤2	0.113	0.61	0.33 to 1.12	0.211	0.82	0.61 to 1.12	0.746	1.15	0.50 to 2.62
>2	0.000	0.16	0.07 to 0.41	0.193	0.80	0.56 to 1.12	0.949	1.04	0.32 to 3.36
Type of surgery (limb-sparing vs amputation)	0.486	1.55	0.45 to 5.32	0.717	0.93	0.61 to 1.40
Radiotherapy
Neoadjuvant		1			1
Adjuvant	0.015	4.36	1.34 to 14.24	0.840	0.96	0.63 to 1.46
No radiotherapy	0.000	14.20	4.14 to 48.75	0.340	1.24	0.80 to 1.91

*Incomplete excision elsewhere prior to referral.

†Malignant peripheral nerve sheath tumour.

‡Not otherwise specified.

§Malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma.

ANED, alive, no evidence of disease; DM, distant metastasis; LR, local recurrence; Trans., transition.