Table 1.

Instruments, assessments and investigations in the study protocol

Battery of Cognitive tests	The Community Screening Instrument for Dementia (CSI‘D’) COGSCORE incorporating the CERAD animal naming verbal fluency task. (CERAD—Consortium to Establish a register for Alzheimer's Disease)37 The modified CERAD 10-word list learning task with delayed recall38 Informant interview, the CSI‘D’ RELSCORE37, for evidence of cognitive and functional decline*
Instruments for diagnosis of dementia	Battery of cognitive tests (listed above) A structured clinical mental state interview, the Geriatric Mental State, which applies a computer algorithm35 An extended informant interview, the history and aetiology schedule—dementia diagnosis and subtype39* The NEUROEX, a brief fully structured neurological assessment40 Behavioural and psychological symptoms: assessed by Neuropsychiatric Inventory41*
Health status and physical health assessment	Self-reported global health by a structured interview†28 Self-reported diagnoses and treatments for these conditions†28 A self-reported list of 12 commonly occurring physical impairments†42 Activity limitation and participation restriction measured by the WHO—Disability Assessment Schedule II†43 Rose Angina Questionnaire32 Direct physical assessments: pulse rate, systolic and diastolic resting blood pressure, weight, height, leg length, head circumference, waist circumference, waist:hip ratio, skin fold thickness (subscapular, triceps and abdominal), calf circumference, hand grip test, bio impedance measurements, 12-lead ECG for Minnesota coding and 5 m walking test Reproductive status (for women)—menarche, menopause, reproductive period and number of children
A structured interview†	Specific cognitive risk factors Lifestyle and cardiovascular risk factors
Socioeconomic assessments	Modified Kuppuswamy Scale44† Standard of Living Index45†
Blood tests and genetic assay	Blood tests: Haemoglobin, glucose tolerance test, lipid profile, albumin, total protein, thyroid function tests, vitamin B12, folate, insulin and creatinineGenetic assay: ApoE lipoprotein

*Instruments administered to informants only.

†Instruments administered to the informants only if the participants have communication difficulties arising from cognitive problems, severe mental illness, deafness or mutism.

ApoE, Apolipoprotein E.