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. 2016 Aug 29;36(7):912–921. doi: 10.1038/onc.2016.256

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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DLL4-overexpressing glioblastoma xenografts show increased vascular FABP4 expression that is sensitive to drug inhibition of NOTCH1 and VEGFA signalling. Formaldehyde fixed-paraffin embedded sections of empty vector (EV) control or DLL4-overexpressing U87 xenografts treated with vehicle control (dimethylsulphoxide, DMSO), the VEGFA-antibody bevacizumab (BEV) and/or the γ-secretase inhibitor dibenzazepine (DBZ, inhibits NOTCH1 signalling) were stained for FABP4 using a mouse and human specific antibody (a), and vascular FABP4 staining (red arrow) was quantified. The percentage of strongly positive vessels is shown (b). Scale bar=100 μm, n=5 per group, *P<0.05; **P<0.01; ****P<0.00001. Error bars, s.d.