Table 1. Demographics of HV and patients with IBS subtypes.
| Median (IQR) | HV (n =34) | IBS-C (n =16) | IBS-D (n =30) | IBS-M (n =11) | P value |
|---|---|---|---|---|---|
| Age | 24 (21–29) | 36 (25–46) | 44 (33–65) | 34 (22–57) | |
| Female: male | 15:19 | 15:1 | 18:12 | 7:4 | χ2 11.26, P=0.01 |
| Anxiety score (0–21) | 2.0 (1.0–4.0) | 10.0 (6.3–12.8)a | 6.5 (3.8–9.0)a | 7.0 (4.0–12.0)a | <0.01 (Kruskal–Wallis) |
| Depression score (0–21) | 3.5 (1.0–5.0) | 4.5 (2.3–7.8) | 3.0 (1.0–5.3) | 5 (2.0–8.0) | 0.18 (Kruskal–Wallis) |
| PHQSS12 | 2.0 (0–3.0) | 8.5 (6.0–10.0)a | 5.0 (2.8–8.0)a | 7.0 (4.0–11.0)a | <0.01 (Kruskal-Wallis) |
| VSI | 1.0 (0–7.5) | 53.0 (40.5–64.0)a | 40 (25.5–51.0)a | 44.0 (32.0–51.0)a | <0.01 (Kruskal-Wallis) |
| IBSSS | 29.5 (10–39) | 340 (258–406)a | 282 (191.5–363.0)a | 265 (189–315)a | <0.01 (Kruskal–Wallis) |
| Perceived stress score | 18.5 (8.3–29.5) | 28.5 (24.3–30.0) | 27.0 (15.5–31.5) | 26.0 (16.0–33.0) | 0.38 (Kruskal–Wallis) |
| Baseline average abdominal pain (0–10) | 0 (0–0.1) | 3.4 (2.5–3.9)a | 3.3 (1.2–3.9)a | 3.7 (2.9–7.6)a | <0.01 (Kruskal–Wallis) |
| Baseline average urgency (0–10) | 0.1 (0–1.0) | 1.9 (0.1–2.6) | 4.7 (2.3–6.7)a,b | 3.4 (1.4–4.7)a | <0.01 (Kruskal–Wallis) |
| Baseline average bloating (0–10) | 0 (0–0.8) | 5.2 (3.7–7.1)a | 2.0 (0.6–5.8)a | 4.4 (2.0–6.9)a | <0.01 (Kruskal–Wallis) |
| Baseline average daily stool frequency | 1.1 (0.9–1.4) | 1.0 (0.6–1.2) | 2.5 (1.8–3.4)a,b | 1.7 (1.3–2.9)b | <0.01 (Kruskal–Wallis) |
| Baseline average stool consistency (1–7) | 3.8 (3.3–4.1) | 2.1 (1.6–3.1) | 5.4 (4.8–5.7)a,b | 4.0 (3.6–4.4)b,c | <0.01 (Kruskal–Wallis) |
HV, healthy volunteers; IBS, irritable bowel syndrome; IBS-C, IBS with constipation; IBS-D, IBS patients with diarrhea; IBS-M, IBS with mixed bowel habit; IQR, interquartile range; VSI, visceral sensitivity index.
a
P<0.01 vs. HV.
b
P≤0.03 vs. IBS-C.
c
P<0.01 vs. IBS-D.