Table 3. Fasting and postprandial AUC (0–360 min) regional colonic volumes and colonic gas volumes.
| Median (IQR) | HV | IBS-C | IBS-nonC | P value |
|---|---|---|---|---|
| Fasting AC (ml) at t =−45 min | 194 (150–234) | 217(191–268) | 209 (147–248) | 0.30 (Kruskal–Wallis) |
| Fasting TC (ml) at t =−45 min | 165 (117–255) | 253 (200–329)a | 198 (106–270)b | <0.01 (Kruskal–Wallis) |
| Fasting DC (ml) at t =−45 min mean (s.d.) | 143 (61) | 153 (47) | 114 (52) | 0.02 (Kruskal–Wallis) |
| Fasting total colonic volume (ml) at t =−45 min mean (s.d.) | 513 (174) | 644 (148)a | 498 (175)b | 0.01 (ANOVA) |
| AUC AC l minc | 67.6 (54.4–86.4) | 76.8 (61.6–92.5) | 65.7 (52.2–78.4) | 0.21 (Kruskal-Wallis) |
| AUC TC volume l min mean (s.d.)c | 67.9 (27.7) | 96.9 (24.6)a | 72.1 (25.8)b | < 0.01 (ANOVA) |
| AUC DC l min mean (s.d.)c | 50.4 (21.2) | 51.8 (18.1) | 41.9 (17.0) | 0.09 (ANOVA) |
| AUC total colonic volume l minc | 179.7 (137.3–231.4) | 224.0 (190.1–251.1) | 172.0 (140.6–227.9)b | 0.03 (Kruskal-Wallis) |
| Fasting total colonic gas (ml) at t =−45 min | 16 (5–68) | 17 (8–36) | 13 (7–24) | 0.69 (Kruskal-Wallis) |
| AUC total colonic gas l minc | 9.8 (3.7–23.0) | 8.8 (4.4–16.3) | 7.71 (4.0–13.5) | 0.70 (Kruskal-Wallis) |
AC, ascending colon; AUC, area under the curve; HV, healthy volunteers; IBS-C, IBS with constipation; IQR, interquartile range; SBWC, small bowel water content; TC, transverse colon.
a
P≤0.03 vs. HV.
b
P≤0.03 vs. IBS-C.
c
AUC for postprandial volume min ml (t=0 to t=360 min) ml min.