Table 1.
Dimensions and Hemodynamic Parameters across Different BM Microvessels
| Vessel Segments (n) | Diameter (μm) | Velocity (mm/s) | RBC Density (%) | RBC Flux pL/s | Viscosity (cP) | Shear Rate (1/s) | Shear Stress (dyn/cm2) | |
|---|---|---|---|---|---|---|---|---|
| Arterial vessel | 9 | 8.0 ± 1.0 (6.9–9.6) | 1.95 ± 0.57 (1.19–2.34) | 73 ± 6 (60–79) | 39.3 ± 22.0 (14.1–25.7) | 3.4 ± 0.2 (3.0–3.6) | 1921 ± 417 (1245 – 2569) | 65.5 ± 16.0 (40.3 – 86.3) |
| Post-arterial capillaries | 5 | 7.8 ± 1.0 (7.1–9.4) | 1.10 ± 0.31 (0.79–1.6) | 62 ± 17 (44–78) | 16.4 ± 6.3 (8.9–21.4) | 3.1 ± 0.5 (2.5–3.5) | 1150 ± 409 (672 – 1766) | 34.6 ± 12.3 (23.8 – 55.6) |
| Intermediate capillaries | 6 | 11.2 ± 1.9 (8.8–16.9) | 0.66 ± 0.18 (0.44–0.89) | 58 ± 16 (38–70) | 15.8 ± 10.9 (6.8–34.0) | 3.0 ± 0.5 (2.3–3.5) | 484 ± 126 (323 – 667) | 14.2 ± 4.7 (10.5 – 22.0) |
| Sinusoidal capillaries | 31 | 21.1 ± 10.7 (9.3–46.2) | 0.23 ± 0.22 (0.07–0.69) | 44 ± 18 (13–75) | 13.6 ± 13.4 (0.6–47.0) | 2.5 ± 0.5 (1.8–3.5) | 119 ± 114 (3 – 339) | 2.9 ± 2.7 (0.06 – 11.1) |
To visualize blood flow TexasRed dextran was intravenously injected, and RBCs were recorded during their passage through the BM microvasculature. Luminal diameters, RBC velocities, and RBC density were determined, and RBC flux, shear rates, and, with estimated viscosities, wall shear stress were calculated. Numbers shown are mean values ± SD, ranges are shown in parentheses, and 51 vessel segments were analyzed from five animals.