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. 2017 Feb 20;15:6. doi: 10.1186/s12959-017-0129-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Differences in clotting time in whole blood (thromboelastometry) after adding haemostatic agents in different concentrations. Differences in clotting time expressed as per cent reduction from baseline (rivaroxaban with no haemostatic agent added). The doses of the haemostatic agents are 80%, 100% and 125% of the suggested doses, as described under study design. Control level, the difference between the mean control value and the patient baseline values, is illustrated by the dotted line. a. Rivaroxaban-treated patients, the whole group, n = 50. b. Subgroup with the highest rivaroxabanconcentrations (>300 ng/L), n = 6. *p < 0.005. PCC: prothrombin complex concentrate, aPCC: activated prothrombin complex concentrate, rFVIIa: recombinant Factor VIIa