Table 3.
Results phase II (n = 9). Laboratory data, microcirculatory variables of small vessels (<20 μm) and bioelectrical impedance analysis before and after intervention
| Variables | Baseline | Post-intervention | p-value |
|---|---|---|---|
| UF isolated | |||
| UF | - | 1.7 [1.2–2] | |
| UF rate, l/h | - | 1.7 [1.2–2]† | |
| MFI, AU | 2.8 [2.5–2.9] | 2.5 [2.2–2.8] | 0.03 |
| TVD, mm/mm2 | 17.7 [16.5–18.4] | 18.7 [16.1–20.3] | 0.26 |
| Hematocrit, % | 37 [35–39] | 39 [36–44] | 0.11 |
| NT-pro-BNP, pmol/l | 599 [215–1702] | 580 [158–1440] | 0.01 |
| Troponine T, ng/l | 90 [60–150] | 87 [56–130] | 0.08 |
| BCM overhydration, l | 1.4 [0.6–3.2] | 0.3 [−0.1–0.8] | 0.02 |
| HD isolated | |||
| UF | – | 0 [0–0] | |
| UF rate, l/h | – | 0 [0–0]† | |
| MFI, AU | 2.8 [2.5–2.9] | 2.8 [2.7–2.9] | 0.61 |
| TVD, mm/mm2 | 17.7 [16.5–18.4] | 18.6 [14.6–19.7] | 0.86 |
| Hematocrit, % | 37 [35–39] | NA | |
| NT-pro-BNP, pmol/l | 599 [215–1702] | NA | |
| Troponine T, ng/l | 90 [60–150] | NA | |
| BCM overhydration, l | 1.4 [0.6–3.2] | NA | |
| HD + linear UF | |||
| UF | 1.7 [1.2–2.1] | ||
| UF rate, l/h | 0.42 [0.3–5.1]† | ||
| MFI, AU | 2.9 [2.5–3] | 2.6 [2.2–2.9] | 0.12 |
| TVD, mm/mm2 | 17.8 [16.6–18.8] | 19.8 [17.9–21.5] | 0.07 |
| Hematocrit, % | 38 [35–40] | 40 [35–41] | 0.18 |
| T-pro-BNP, pmol/l | 618 [279–1926] | 536 [167–1003] | 0.01 |
| Troponine T, ng/l | 94 [61–179] | 84 [62–139] | 0.02 |
| BCM overhydration, l | 1.8 [0.5–5.3] | 0.3 [−0.9–3.2] | 0.02 |
| HD + BVM-guided UF | |||
| UF | 2.0 [1.5–2.1] | ||
| UF rate, l/h | 0.5 [0.39–0.52]† | ||
| MFI, AU | 2.8 [2.5–3] | 2.8 [1.9–2.9] | 0.06 |
| TVD, mm/mm2 | 18.8 [16.8–20.6] | 18.2 [16.9–20.6] | 0.77 |
| Hematocrit, % | 37 [34–39] | 39 [35–42] | 0.12 |
| NT-pro-BNP, pmol/l | 574 [229–2011] | 511 [172–1163] | 0.01 |
| Troponine T, ng/l | 81 [54–379] | 79 [54–387] | 0.12 |
| BCM overhydration, l | 2.4 [1.5–5.1] | 0.2 [−0.9–4.2] | 0.04 |
UF ultrafiltration, HD hemodialysis, BVM blood volume monitoring, MFI microvascular flow index, TVD total vessel density, PPV percentage of perfused vessels, NT-pro-BNP n-terminal pro b-type natriuretic peptide, BCM body composition monitoring † p < 0.001 across different HD/UF modalities