Table 3.
GOLD B (n = 51) | GOLD D (n = 19) | p - value | |
---|---|---|---|
Demographics | |||
Gender (% Male) | 75.6 | 52.6 | 0.15 |
BMI (Kg/m2) | 27.0 [16.2–44.8] | 27.7 [21.7–48.5] | 0.32 |
FFMI (Kg/m2) | 18.3 [8.8–24.0] | 17.6 [11.7–27.0] | 0.75 |
Exacerbations (1 year prior) | 0.0 [0.0–1.0] | 2.0 [0.0–4.0] | <0.0001 |
Patient reported outcomes | |||
SGRQ total | 41.1 (15.5) | 50.0 [22.2–82.3] | 0.001 |
SGRQ symptoms | 54.6 (19.9) | 61.0 (17.5) | 0.24 |
SGRQ impact | 26.3 [2.1–71.6] | 42.4 [4.6–60.1] | 0.05 |
SGRQ activity | 59.3 [0.0–100.0] | 78.1 [22.5–100.0] | 0.003 |
CAT | 15.5 [9.0–35.0] | 20.0 [9.0–37.0] | 0.018 |
CES-D | 12.0 [0.0–33.0] | 15.0 [0.0–31.0] | 0.58 |
Functional capacity | |||
6MWD (metres) | 440.5 (125.7) | 347.3 (123.4) | 0.023 |
Lung function | |||
Vital capacity % | 99.2 (21.9) | 93.6 (13.1) | 0.40 |
Total lung capacity % | 110.2 (17.0) | 110.5 (23.5) | 0.96 |
Residual volume % | 132.0 (30.4) | 150.0 (55.9) | 0.16 |
Inspiratory capacity % | 93.1 (21.8) | 91.4 (20.9) | 0.81 |
FRC % | 125.6 (25.7) | 132.5 (45.9) | 0.52 |
DLCO % | 56.5 [40.0–102.0] | 61.5 [32.0–115.0] | 0.87 |
KCO % | 75.5 (80.1) | 74.7 (85.0) | 0.53 |
VA % | 81.4 (13.1) | 76.9 (14.2) | 0.29 |
Post FEV1 % | 68.2 (12.3) | 57.3 (12.8) | 0.002 |
Reversibility % | −4.4 [−53.8–+8.0] | −8.1 [17.3–+8.3] | 0.25 |
Reversibility mls | 20.0 [−170.0–580] | 90 [−120–200] | 0.90 |
Change in FEV1 from baseline | −80.0 [−420.0–+939.0] | −120.0 [−531.0–+180.0] | 0.07 |
Bacteriology | |||
Bacterial load (genome copies/ml) | 2.36 × 106 [0–8.89 × 108] | 10.3 × 107 [0–1.76 × 108] | 0.25 |
Colonised (% >1 × 104 total PPM) | 71.4 | 77.2 | 1.00 |
Systemic inflammation | |||
CRP (mg/L) | 3.0 [1.0–20.0] | 5.0 [2.0–20.0] | 0.017 |
WBC (109/L) | 6.9 [3.6–13.5] | 7.5 [4.8–11.8] | 0.73 |
Eosinophils (109/L) | 0.2 [0.1–0.6] | 0.2 [0.0–0.4] | 0.24 |
Summaries are presented as mean (SD), percentage or Median [Range] as appropriate
Definitions of abbreviations: BMI body mass index, FFMI fat free mass index, SGRQ St George’s Respiratory Questionnaire, CAT COPD assessment test, CES-D Centre for Epidemiologic Studies Depression, 6MWD six minute walk distance, FRC functional residual capacity, DLCO diffusing capacity of the lungs for carbon monoxide, KCO carbon monoxide transfer coefficient, VA alveolar volume, CRP C-reactive protein, WBC white blood count, PPM potentially pathogenic microorganisms