Age |
47 |
25 |
55 |
Sex |
Male |
Male |
Male |
Prior therapies (no.) |
6 |
6 |
5 |
Stem cell source |
Matched-related |
Matched-related |
Haploidentical and umbilical cord blood |
Conditioning regimen |
Reduced intensity |
Reduced intensity |
Reduced intensity |
T cell depleted graft |
Yes |
Yes |
Yes |
Prior GVHD |
No |
Chronic GVHD of gut |
Chronic oral GVHD |
Days to relapse following AlloHSCT (no.) |
181 |
2456 |
389 |
Localization and size of relapse |
Diffuse bone and splenic involvement |
Multifocal adenopathy in mediastinum, retroperitoneum and pelvis. Largest lymph node 2.3 × 1.5 cm in mediastinum |
Multifocal adenopathy in neck, chest, abdomen and pelvis. Largest lymph node 4.2 × 1.8 cm in right axilla |
Prior DLI |
No |
Yes |
No |
Immune-related adverse events |
Grade 2 Keratoconjunctivitis |
Grade 3 Inflammatory polyarthritis and grade 2 keratoconjunctivitis |
Grade 1 Rash |
Response to nivolumab |
Partial response |
Partial response |
Partial response |
Duration of response |
6 Months+ |
10 Months+ |
14 Months+ |
Donor CD3+ chimerism before and after treatment |
18 to 49% |
Not available |
Not available |