Figure 1.

Glial kon/NG2 gene network for central nervous system (CNS) repair.

Illustration showing the gene network operating in the glial regenerative response to CNS injury in neuropile glia of the Drosophila larva, compared to oligodendrocyte progenitor cells and oligodendrocytes in mammals. (A) Quiescence state of the normal CNS. (B) The glial response to CNS injury starts with the induction of glial proliferation. (C) During repair, cell proliferation is switched off, and glial differentiation is activated, re-establishing axonal enwrapment and CNS integrity. Arrows indicate ‘gene activation’; block lines indicate ‘gene repression’; their ‘grey’ colouring indicates known genetic interactions; ‘red’ indicates active during injury or during repair; ‘dashed lines’ indicate unknown genetic relationships.