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Co-ligation of FcγRIIB with the BCR. The Fc portion of anti-Id binds to the B lymphocyte’s FcγRIIB. Simultaneously the Fab portion of anti-Id binds to the BCR, thereby co-ligating these two membrane proteins. Co-ligation of the FcγRIIB to the BCR abolishes the BCR-induced stimulation of antibody secretion.
