TABLE I.

NHLBI Sponsored/Collaborative Trials Closed for Slow Enrollment or Poor Accrual Since 2008

Hydroxyurea and magnesium pidolate to treat people with hemoglobin sickle cell disease

Dexamethasone to treat acute chest syndrome in people with sickle cell disease

Ketorolac versus ibuprofen to treat painful episodes of sickle cell disease

The improve trial: improving pain management and outcomes with various strategies of patient-controlled analgesia (PCA)

A study of patients having pulmonary hypertension associated with sickle cell disease and completing an asset study (ASSET-3)

11 Additional non-NHLBI sponsored trials listed on clinical trials.gov closed for slow accrual