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. 2017 Jan 19;3:1. doi: 10.1038/s41523-016-0001-7

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© The Author(s) 2017

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Fig. 2 — Knockdown of mtp53 identifies enrichment of the pre-replicative complex pathway. GSEA analysis revealed a total of 27 and 17 Reactome pathways that are positively and negatively, respectively, associated with mtp53 abundance at a nominal P value < 1%. Enrichment of five DNA replication-related gene sets and pathways including the pre-replicative complex consisting of 15 genes, shown here with their enrichment scores (upper panel) and mutant p53 association index (mPAI) ranks (lower panel). Full GSEA results are available at http://diverge.hunter.cuny.edu/~weigang/silac-chromatin-gsea/ (chromatin) and http://diverge.hunter.cuny.edu/Polotskaia_etal_2014/supp-table-s1/ (cytosol)