Figure 1.
Using ASL to measure regional CBF. The panels in the first row display the process of obtaining ASL-measured CBF in GM: (A) 3D T1-scan; (B) GM probability map; (C) GM mask, obtained by WM thresholding the probability map at P > 0.8; (D) CBF map; (E) masked GM CBF map. The panels in the second row show the same process for WM CBF: (F) 3D T1-scan; (G) WM probability map; (H) WM mask, obtained by thresholding the WM probability map at P > 0.8 and eroding with a 7.5 mm disk to avoid GM contamination; (I) CBF map; (J) masked WM CBF map. The basal ganglia and thalamus regions, as defined using the Harvard Oxford atlas, are displayed in panel (B): caudate nucleus (orange), putamen (green), nucleus accumbens (blue), and thalamus (red). Note that the thalamus region contains both GM and WM, which is why it was not further masked using the participant-specific GM mask. ASL = arterial spin labeling, CBF = cerebral blood flow, GM = gray matter, WM = white matter.